GSCN workshop
New developments in disease modeling and drug discovery
16 & 17 Nov. 2023
LIFE & BRAIN, Bonn, Venusberg-Campus 1, building 76, 53127 Bonn, Germany
This two-day workshop brought together experts from stem cell-based disease modeling and drug development and address the latest developments in this rapidly expanding field.
The event featured expert talks from academia and pharma, moderated discussion rounds and short project vignettes by the workshop participants.
Topics that have been addressed ranged from biological and infrastructural prerequisites for stem cell-based drug discovery to strategic issues such as proper placement of stem cell tools in the pharmaceutical value chain.
We had a focused and highly interactive event on the beautiful Bonn Medical Campus!
Speaker list:
Flyer ↓ here
Program:
Thursday, 16 November 2023
| until 12:00 |
individual arrival at LIFE & BRAIN, Bonn, Venusberg-Campus 1, building 76, 53127 Bonn, Germany |
| 12:00 - 12:10 |
Welcome
Daniel Besser, GSCN / BIH @ Charité & Oliver Brüstle, LIFE&BRAIN GmbH |
| |
I. Biology: Prerequisites for high fidelity hPSC-based drug discovery |
| 12:10 - 12:30 |
Progress and challenges in neural disease modelling
Oliver Brüstle, LIFE&BRAIN GmbH |
| 12:30 - 13:00 |
Standardization & QC: (inter) national approaches for harmonization in iPSC production
Harald Stachelscheid, BIH/Charité, Berlin |
| 13:00 - 13:30 |
Modeling physical forces with iPSCs: Requirements for heart diseases
Karl-Ludwig Laugwitz, TU Munich |
| 13:30 - 14:00 |
Human stem cell-derived dopaminergic neuron and microglia models for phenotypic drug discovery
Johannes Wilbertz, Ksilink Strasbourg |
| 14:00 - 14:45 |
Lunch break in the LIFE&BRAIN foyer |
| 14:45 - 15:15 |
iPS cells as important tool to support drug development
Florian Meier, Boehringer Ingelheim |
| 15:15 - 16:30 |
Short statements by all participants
Selected project vignettes (5 min each, 9 presentations)
Workshop participants |
| 16:30 - 16:50 |
Coffee break |
| |
Workshop Discussion Round I |
| 16:50 - 17:15 |
Cellular requirements for hPSCs and derivatives
Moderators: Karl-Ludwig Laugwitz & Michael Peitz |
| 17:15 - 17:40 |
Process standardization, scaling and automation
Moderators: Harald Stachelscheid & Johannes Wilbertz |
| 17:40 - 18:05 |
Shaping appropriate read-outs
Moderators: Florian Meier & Jutta Meyer |
| 19:30 - 22:00 |
Joined dinner at "S im Carré" (included) |
Friday, 17 November 2023
| |
II. Strategy: Efficient allocation of hPSC tools in pharmaceutical value chains |
| 09:00 - 09:30 |
iPSC based models: how to slot them in the drug development process?
Jan Eickhoff, LDC Dortmund |
| 09:30 - 10:00 |
Small molecule drug discovery using iPS-derived assays: drug repurposing vs. novel compounds
Ole Pless, Fraunhofer ITMP |
| 10:00 - 10:30 |
Role of iPSC-derived models in preclinical R&D at Bayer AG
Jutta Meyer & Manuel Grundmann, Bayer AG |
| 10:30 - 11:00 |
Advancing drug discovery through precision medicine using iPSC and transcriptomics data
Sandra Lubitz & Henrik Renner, Evotec AG, Hamburg |
| 11:00 - 11:30 |
Coffee break |
| |
Workshop Discussion Round II |
| 11:30 - 12:00 |
Where is the right place of iPSC models in the drug development process?
Moderators: Sandra Lubitz & Ole Pless |
| 12:00 - 12:30 |
The academia - pharma interface: Financial incentives for early value chain contributions
Moderators: Jan Eickhoff & Karl-Ludwig Laugwitz |
| |
Wrap Up & Quo Vadis |
| 12:30 - 13:00 |
Compiling the key challenges and requirements identified in the workshop
Oliver Brüstle & Jan Eickhoff |
| 13:00 - 14:00 |
Lunch in the LIFE&BRAIN foyer & departure |